CAC1A Polyclonal Antibody

BT-AP01081                                      IHC-p

Description

Cat.No. BT-AP01081  Size: 100ul/50ul/20ul    Datasheet Request  

Product Information

Clonallity: Polyclonal

Applications: IHC-p

Source: Rabbit

Immunogen: Synthesized peptide derived from human protein at AA range: 1401-1450

Protein Name: Voltage-dependent P/Q-type calcium channel subunit alpha-1A

Species reactivity: human

Concentration: 1 mg/ml

Observed molecular weight: 275 kDa

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Recommended Dilution:

IHC: 1:50 – 1:300

Not yet tested in other applications

Synonyms: Brain calcium channel I;BI;Calcium channel, L type, alpha-1 polypeptide isoform 4;Voltage-gated calcium channel subunit alpha Cav2.1

Storage:

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C.

Background:

calcium voltage-gated channel subunit alpha1 A(CACNA1A) Homo sapiens Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2.