HP-1 Alpha mouse Monoclonal Antibody(2G2)

BT-MCA0817                                      WB,IHC-p

Description

Cat.No. BT-MCA0817  Size: 100ul/50ul/20ul    Datasheet Request  

Product Information

Clonallity: Monoclonal

Applications: WB,IHC-p

Source: Mouse

Immunogen: Recombinant Protein of HP-1 alpha.

Protein Name: Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha).

Species reactivity: Human,Mouse,Rat

Concentration: 1 mg/ml

ConcentraObserved molecular weight: 22 kDa

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Recommended Dilution:

WB: 1:500 – 2000

IHC-p: 1:50 – 300

Synonyms: Chromobox protein homolog 5;Antigen p25;Heterochromatin protein 1 homolog alpha;HP1 alpha

Storage:

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C.

Background:

CBX5 (chromobox 5) encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. CBX5 has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.