BT-MCA0821 IF,WB,IHC-p
Description
Cat.No. BT-MCA0821 Size: 100ul/50ul/20ul Datasheet Request
Product Information
Clonallity: Monoclonal
Applications: IF,WB,IHC-p
Source: Mouse
Protein Name: Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein).
Immunogen: Recombinant Protein of HP-1 gamma.
Species reactivity: Human,Mouse,Rat
Concentration: 1 mg/ml
ConcentraObserved molecular weight: 24 kDa
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Recommended Dilution:
IF: 1:50 – 200
WB: 1:500 – 2000
IHC-p: 1:50 – 300
Synonyms: Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)
Storage:
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C.
Background:
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by CBX3 (chromobox 3) binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5′ UTR, have been found for CBX3.