HSPB8/HSP22 Monoclonal Antibody(2C3)

BT-MCA0851                                      WB

Description

Cat.No. BT-MCA0851  Size: 100ul/50ul/20ul    Datasheet Request  

Product Information

Clonallity: Polyclonal

Applications: WB

Source: Mouse

Immunogen: Recombinant Protein of HSPB8/HSP22.

Protein Name: Heat shock protein beta-8 (HspB8) (Alpha-crystallin C chain) (E2-induced gene 1 protein) (Protein kinase H11) (Small stress protein-like protein HSP22).

Species reactivity: Human,Rat,Mouse

Concentration: 1 mg/ml

Observed molecular weight: 22 kDa

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Purification:

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Recommended Dilution:

WB: 1:1000 – 2000

Not yet tested in other applications

Synonyms: HSPB8; CRYAC; E2IG1; HSP22; PP1629; Heat shock protein beta-8; HspB8; Alpha-crystallin C chain; E2-induced gene 1 protein; Protein kinase H11; Small stress protein-like protein HSP22

Storage:

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C.

Background:

heat shock protein family B (small) member 8(HSPB8) Homo sapiens The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.