Tel:86 021 3100 7137

Publish and get free product : share with us your publications using BT LAB product and get free products.
Home > Product > Recombinant proteins > Recombinant Human Interleukin-21

Recombinant Human Interleukin-21

Recombinant Human Interleukin-21

Product Summary

Size: 2ug

Purity: > 97 % by SDS-PAGE and HPLC analyses.

Source: Escherichia coli.

Product Summary

Size: 2ug

Purity: > 97 % by SDS-PAGE and HPLC analyses.

Source: Escherichia coli.

Product overview

Product name

Recombinant Human Interleukin-21

Code

CD0102

Biological activity

Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human N1186 T cells is less than 20 ng/ml, corresponding to a specific activity of > 5.0 × 104 IU/mg.

Endotoxin

Less than 1 EU/μg of rHuIL-21 as determined by LAL method.

Synonyms

IL-21;IL21; IL 21

Sequence

QGQDRHMIRM RQLIDIVDQL KNYVNDLVPE FLPAPEDVET NCEWSAFSCF QKAQLKSANT GNNERIINVS IKKLKRKPPS TNAGRRQKHR LTCPSCDSYE KKPPKEFLER FKSLLQKMIH QHLSSRTHGS EDS

Uniprot Accession

Molecular Weight

Approximately 15.4 kDa, a single non-glycosylated polypeptide chain containing 133 amino acids.

Formulation

Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.

Background

Human IL-21 is encoded by IL-21 gene located on Chr. 4. It is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation and can regulating immune system cells, for instance cytotoxin T cells and natural killer cells. Additionally, it can induce target cells division or proliferation. IL-21 elicits its effect through binding to IL-21R, which also contains the gamma chain found in other cytokine receptors such as IL-2, IL-4, IL-7, IL-9 and IL-15. IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. IL-21 shows having much relation with clinical illnesses, including cancer immunotherapy, viral infections and allergies.

Storage

-20ºC

Research area

Others

Images

Protocols

References

Customer reviews and Q&As

No reviews.
No reviews
  • Size

    Code

    Price

  • 2ug

    CD0102

    $128.00

Add to Cart

Lead time: Within two weeks

We are continuously updating our Recombinant proteins catalog with advanced verified products. If you can not download the datasheet please send your request of our latest datasheet.

Newsletter

Sign up

Newsletter

Sign up