Biogenesis of lysosome-related organelles complex 1 subunit 1

E6559Hu

Sandwich

48T,96T

4.68ng/L

10-2000ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (PubMed:17182842). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9.

17,263

2647

Biogenesis of lysosome-related organelles complex 1 subunit 1;BLOC-1 subunit 1;BLOC1S1;BLOS1;BORCS1;GCN5L1;GCN5-like protein 1;MICoA;Protein RT14;RT14

BLOC1S1

Cardiovascular; Signal Transduction

BLOC1S1