Chondroitin Sulfate Proteoglycan 4

E1936Mo

Sandwich

48T,96T

9.51mU/mL

20-2000mU/mL

Serum, plasma, cell culture supernates

Mouse

2-8ºC

1h 30m

Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.

252,309

121021

Chondroitin sulfate proteoglycan 4;Chondroitin sulfate proteoglycan NG2;CSPG 4;CSPG4;Proteoglycan AN2

CSPG4

Others

CSPG4