Clusterin

E1189Hu

Sandwich

48T,96T

0.31ng/ml

0.5-300ng/ml

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

[Isoform 1]: Functions as extracellular chaperone that prevents aggregation of non native proteins (PubMed: 11123922, PubMed: 19535339). Prevents stress-induced aggregation of blood plasma proteins (PubMed: 11123922, PubMed: 12176985, PubMed: 17260971, PubMed: 19996109). Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro) (PubMed: 12047389, PubMed: 17412999, PubMed: 17407782). Does not require ATP (PubMed: 11123922). Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70 (PubMed: 11123922). Does not refold proteins by itself (PubMed: 11123922). Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation (PubMed: 21505792). Protects cells against apoptosis and against cytolysis by complement (PubMed: 2780565). Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed: 20068069). Promotes proteasomal degradation of COMMD1 and IKBKB (PubMed: 20068069). Modulates NF-kappa-B transcriptional activity (PubMed: 12882985). A mitochondrial form suppresses BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis (PubMed: 16113678, PubMed: 17689225). Plays a role in the regulation of cell proliferation (PubMed: 19137541). An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5 (PubMed: 22689054). Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed: 24073260). Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity). [Isoform 6]: Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity. [Isoform 4]: Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed: 24073260). Promotes cell death through interaction with BCL2L1 that releases and activates BAX (PubMed: 21567405).

52,495

1191

Aging-associated gene 4 protein;Apo-J;ApoJalpha;ApoJbeta;Apolipoprotein J;CLI;CLU;Clusterin;Clusterin alpha chain;Clusterin beta chain;Complement cytolysis inhibitor;Complement cytolysis inhibitor a chain;Complement cytolysis inhibitor b chain;Complement-associated protein SP-40,40;Ku70-binding protein 1;NA1/NA2;SGP-2;Sulfated glycoprotein 2;Testosterone-repressed prostate message 2;TRPM-2

CLU

Cardiovascular

CLU