Angiopoietin-Like Protein 4

E0042Bo

Sandwich

96T,48T

0.45ng/ml

1-310ng/ml

Serum, plasma, cell culture supernates

Bovine

2-8ºC

1h 30m

Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (By similarity). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro) (By similarity). Depending on context, may modulate tumor-related angiogenesis (By similarity). [ANGPTL4 N-terminal chain]: Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. Has higher activity in LPL inactivation than the uncleaved protein.

45,553

509963

Angiopoietin-like protein 4;Angiopoietin-related protein 4;ANGPTL 4;ANGPTL4;ANGPTL4 C-terminal chain;ANGPTL4 N-terminal chain

ANGPTL4

Cardiovascular; Cancer; Metabolism

ANGPTL4