Atp-Binding Cassette Sub-Family A Member 2

E2421Hu

Sandwich

48T,96T

4.57ng/L

10-2000ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Probable lipid tranporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (PubMed: 15238223, PubMed: 21810484, PubMed: 24201375) (Probable). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes (PubMed: 24201375). In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP (PubMed: 22086926, PubMed: 26510981). May play a role in myelin formation (By similarity).

269,833

20

ABCA 2;ABCA2;ATP-binding cassette 2;ATP-binding cassette sub-family A member 2;ATP-binding cassette transporter 2

ABCA2

Others

ABCA2