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Home > Product > Antibody > phospho-MLKL (S358) mouse Monoclonal Antibody(6F8)

phospho-MLKL (S358) mouse Monoclonal Antibody(6F8)

phospho-MLKL (S358) mouse Monoclonal Antibody(6F8)

Product Summary

Size: 20ul,50ul,100ul

Clonality: Monoclonal

Host: Mouse

Reactivity:Human

Applications: IF, ICC, IHC-p

Product Summary

Size: 20ul,50ul,100ul

Clonality: Monoclonal

Host: Mouse

Reactivity: Human

Applications: IF, ICC, IHC-p

Product overview

Full product name

MLKL

Code

BT-MCA1026

Host

Mouse

Isotype

IgG

Size

20ul,50ul,100ul

Clonality

Monoclonal

Immunogen

Synthetic Peptide of phospho-MLKL (S358)

Purification

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Concentration

1 mg/ml

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

-20°C for one year

Background

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain| however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.

Uniprot accession

Molecular weight

N/A

Gene ID

Human: 197259

Synonyms

MLKL

Research area

Signal transduction; Cancer; Microbiology

Target protein

MLKL

Recommended dilution

Application Dilution
IF 1:50-200
IHC 1:100-200

Images

Immunohistochemical analysis of paraffin-embedded Human-breast-cancer tissue. 1.phospho-MLKL (S358) Mouse Monoclonal antibody(6F8) was diluted at 1:200(4°C,overnight). 2.Sodium citrate pH 6.0 was used for antibody retrieval(>98°C,20min). 3.Secondary antibody was diluted at 1:200(room temperature, 30min). Negative control was used by secondary antibody only.
Immunohistochemical analysis of paraffin-embedded Human Colon Carcinoma Tissue using Phospho-MLKL S358 Mouse Monoclonal antibody diluted at 1:200.
Immunohistochemical analysis of paraffin-embedded Human Skin Tissue using Phospho-MLKL S358 Mouse Monoclonal antibody diluted at 1:200.

Protocols

Customer reviews and Q&As

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Product size

Price

  • 20ul

    $108.00

  • 50ul

    $180.00

  • 100ul

    $275.00

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Lead time: Within one week

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