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Home > Product > Antibody > MUM1 Polyclonal Antibody

MUM1 Polyclonal Antibody

MUM1 Polyclonal Antibody

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity:Human, Mouse, Rat

Applications: WB, ELISA

Product Summary

Size: 20ul,50ul,100ul

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, ELISA

Product overview

Full product name

MUM1 Antibody

Code

BT-AP05664

Host

Rabbit

Isotype

IgG

Size

20ul,50ul,100ul

Clonality

Polyclonal

Immunogen

The antiserum was produced against synthesized peptide derived from the C-terminal region of human MUM1. AA range:661-710

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage

-20°C for one year

Background

DNA double-strand breaks (DSBs) are potentially hazardous lesions that can be induced by ionizing radiation (IR), radiomimetic chemicals, or DNA replication inhibitors. Melanoma associated antigen (mutated) 1 (MUM1, EXPAND1) is a PWWP-domain containing chromatin binding protein involved in maintaining chromatin architecture of interphase chromosomes. In response to DNA damage, EXPAND1/MUM1 accumulates at sites of DNA double strand breaks through direct interaction with DNA repair factor 53BP1. Accumulation of EXPAND1/MUM1 at damaged DNA sites is thought to modify the structure of the chromatin and allow access to other DNA repair factors. 53BP1 activates the checkpoint kinase ATM and promotes DNA double strand break repair via nonhomologous end joining (NHEJ) repair pathway.

Uniprot accession

Molecular weight

78636

Gene ID

Human: 84939; Mouse: 68114

Synonyms

melanoma associated antigen (mutated) 1

Research area

Cancer

Target protein

IRF4

Recommended dilution

Application Dilution
WB 1: 500 - 2000
ELISA 1: 10000 - 20000

Images

Western Blot analysis of mouse-kidney mouse-heart mouse-brain cells using MUM1 Polyclonal Antibody diluted at 1:1000. Secondary antibody was diluted at 1:20000

Protocols

Customer reviews and Q&As

No reviews
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Product size

Price

  • 20ul

    $108.00

  • 50ul

    $180.00

  • 100ul

    $275.00

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Lead time: Within one week

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