Product name
Recombinant Human PTHrP protein, 15N
Code
CD01026
Biological activity
Data not available.
Endotoxin
Less than 0.1 EU/μg of rHuPTHrP, 15N as determined by LAL method.
Synonyms
PTHLH,BDE2, HHM, PLP, PTHR, PTHRP,PTHrP, Human
Sequence
AVSEHQLLHD KGKSIQDLRR RFFLHHLIAE IHTAEIRATS EVSPNSKPSP NTKNHPVRFG SDDEGRYLTQ ETNKVETYKE QPLKTP
Uniprot Accession
Molecular Weight
Approximately 10033 Da, a single non-glycosylated polypeptide chain containing 86 amino acids. 15N stable isotope labeled.
Formulation
Lyophilized from a 0.2 μm filtered concentrated solution in 10 mM PB, pH 6.0, 300 mM NaCl.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 C. Further dilutions should be made in appropriate buffered solutions.
Background
Parathyroid Hormone-like related Protein (PTHrP) is a member of the Parathyroid hormone family that is expressed in the mammary gland. It is known as a potent inhibitor of chondrocyte maturation. PTHrP is expressed by periarticular perichondrial cells and exerts its biological activity on PP-R expressing cells. During endochondral bone development PTHrP plays a major role in suppressing the onset of hypertrophic differentiation. PTHrP plays a central role in regulating the extracellular concentrations of calcium and phosphorous and it is responsible for most cases of humoral hypercalcemia of malignancy.
Storage
-20ºC
Research area
Others
