Recombinant Exendin-4 protein

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Home > Product > Recombinant proteins > Recombinant Exendin-4 protein

Recombinant Exendin-4 protein

Product Summary

Size: 100 ug,20 ug

Purity: > 96 % by SDS-PAGE and HPLC analyses.

Source: Escherichia coli.

Product Summary

Size: 100 ug,20 ug

Purity: > 96 % by SDS-PAGE and HPLC analyses.

Source: Escherichia coli.

Product overview

Product name

Recombinant Exendin-4 protein

Code

CD02416

Biological activity

1. Regulates Glucose levels rapidly; 2. Reduces Insulin resistance; 3. Reduces Glucagon; 4. Reduces HbA1c; 5. Stimulates beta cell growth which stimulates insulin production.

Endotoxin

Less than 10 EU/mg of rExendin-4 as determined by LAL method.

Synonyms

Exendin-4, Recombinant

Sequence

HGEGTFTSDL SKQMEEEAVR LFIEWLKNGG PSSGAPPPS

Uniprot Accession

P26349

Molecular Weight

Approximately 4.2 kDa, a single non-glycosylated polypeptide chain containing 39 amino acids.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS, pH 7.4.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.

Background

Exendin-4 is a novel 39-amino acid peptide isolated from the venom of the Gila monster Heloderma suspectum. It shares 53 % sequence homology with GLP-17-36amide and interacts with the same membrane receptor. Exendin-4 enhances glucose-dependent insulin secretion, suppresses inappropriately elevated glucagon secretion, and slows gastric emptying in vivo. It also promotes -cell proliferation and neogenesis in vitro and in animal models. Recombinant Exendin-4 is E. coli expression of a synthetic DNA sequence encoding the 39 amino acid of Exendin-4.

Storage

-20ºC

Research area

Others

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Datasheet

Size

Code

Price

100 ug

CD02416

$204.00
20 ug

CD02416

$176.00

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Lead time: Within two weeks

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