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Home > Product > Antibody > Akt1 Monoclonal Antibody

Akt1 Monoclonal Antibody

Akt1 Monoclonal Antibody

Product Summary

Size: 50ul,100ul

Clonality: Monoclonal

Host: Mouse

Reactivity:Human, Mouse, Rat, Bovine, Chicken, Pig

Applications: WB

Product Summary

Size: 50ul,100ul

Clonality: Monoclonal

Host: Mouse

Reactivity: Human,Mouse,Rat,Bovine,Chicken,Pig

Applications: WB

Product overview

Full product name

RAC-alpha serine,threonine-protein kinase

Code

BT-MCA0144

Host

Mouse

Isotype

IgG

Size

50ul,100ul

Clonality

Monoclonal

Immunogen

Purified recombinant human Akt1 (C-terminus) protein fragments expressed in E.coli.

Purification

Affinity purification

Concentration

1 mg/ml

Formulation

Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.

Storage

-20°C for one year

Background

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.

Uniprot accession

Molecular weight

N/A

Gene ID

Human: 207; Mouse: 11651; Rat: 24185

Synonyms

AKT1; PKB; RAC; RAC-alpha serine; threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha

Research area

Cancer; Signal transduction; Metabolism; Epigenetics and nuclear signaling

Target protein

AKT1

Recommended dilution

Application Dilution
WB 1:1000 - 1:2000

Images

Western Blot analysis using Akt1 Monoclonal antibody against C2C12. K562 cell lysate.

Protocols

References

Customer reviews and Q&As

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Product size

Price

  • 50ul

    $180.00

  • 100ul

    $300.00

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Lead time: Within one week

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