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Home > Product > Antibody > Crk II Monoclonal Antibody

Crk II Monoclonal Antibody

Crk II Monoclonal Antibody

Product Summary

Size: 50ul,100ul

Clonality: Monoclonal

Host: Mouse

Reactivity:Human

Applications: WB, IHC-p, IF, ICC, FCM, ELISA

Product Summary

Size: 50ul,100ul

Clonality: Monoclonal

Host: Mouse

Reactivity: Human

Applications: WB, IHC-p, IF, ICC, FCM, ELISA

Product overview

Full product name

Adapter molecule crk

Code

BT-MCA0385

Host

Mouse

Isotype

IgG

Size

50ul,100ul

Clonality

Monoclonal

Immunogen

Purified recombinant fragment of human Crk II expressed in E. Coli.

Purification

Affinity purification

Concentration

1 mg/ml

Formulation

Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.

Storage

-20°C for one year

Background

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

Uniprot accession

Molecular weight

N/A

Gene ID

Human: 1398

Synonyms

CRK; Adapter molecule crk; Proto-oncogene c-Crk; p38

Research area

Signal transduction; Cancer

Target protein

CRK

Recommended dilution

Application Dilution
FC 1:200 - 1:400
IF 1:200 - 1:1000
IHC 1:200 - 1:1000
WB 1:500 - 1:2000

Images

Western Blot analysis using Crk II Monoclonal antibody against HEK293 (1) and CRK-hIgGFc transfected HEK293 (2) cell lysate.
Immunohistochemistry analysis of paraffin-embedded rectum cancer tissues with DAB staining using Crk II Monoclonal antibody.
Immunofluorescence analysis of 3T3-L1 cells using Crk II Monoclonal antibody (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Flow cytometric analysis of MCF-7 cells using Crk II Monoclonal antibody (blue) and negative control (red).

Protocols

References

Customer reviews and Q&As

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Product size

Price

  • 50ul

    $180.00

  • 100ul

    $300.00

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Lead time: Within one week

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