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Home > Product > Antibody > Cyclin D1 Monoclonal Antibody

Cyclin D1 Monoclonal Antibody

Cyclin D1 Monoclonal Antibody

Product Summary

Size: 50ul,100ul

Clonality: Monoclonal

Host: Mouse

Reactivity:Human

Applications: WB, ELISA

Product Summary

Size: 50ul,100ul

Clonality: Monoclonal

Host: Mouse

Reactivity: Human

Applications: WB, ELISA

Product overview

Full product name

G1,S-specific cyclin-D1

Code

BT-MCA0396

Host

Mouse

Isotype

IgG

Size

50ul,100ul

Clonality

Monoclonal

Immunogen

Purified recombinant fragment of human Cyclin D1 expressed in E. Coli.

Purification

Affinity purification

Concentration

1 mg/ml

Formulation

Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.

Storage

-20°C for one year

Background

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

Uniprot accession

Molecular weight

N/A

Gene ID

Human: 595

Synonyms

CCND1; BCL1; PRAD1; G1; S-specific cyclin-D1; B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; PRAD1 oncogene

Research area

Epigenetics and nuclear signaling; Cell biology; Cancer

Target protein

CCND1

Recommended dilution

Application Dilution
ELISA 1:10000
WB 1:500 - 1:2000

Images

Western Blot analysis using Cyclin D1 Monoclonal antibody against CCND1-hIgGFc transfected HEK293 cell lysate.

Protocols

References

Customer reviews and Q&As

No reviews
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Product size

Price

  • 50ul

    $180.00

  • 100ul

    $300.00

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Lead time: Within one week

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