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Home > Product > Antibody > Neu Monoclonal Antibody

Neu Monoclonal Antibody

Neu Monoclonal Antibody

Product Summary

Size: 50ul,100ul

Clonality: Monoclonal

Host: Mouse

Reactivity:Human

Applications: WB, IHC-p, IF, ELISA

Product Summary

Size: 50ul,100ul

Clonality: Monoclonal

Host: Mouse

Reactivity: Human

Applications: WB, IHC-p, IF, ELISA

Product overview

Full product name

Receptor tyrosine-protein kinase erbB-2

Code

BT-MCA0942

Host

Mouse

Isotype

IgG

Size

50ul,100ul

Clonality

Monoclonal

Immunogen

Purified recombinant fragment of human Neu (aa750-987) expressed in E. Coli.

Purification

Affinity purification

Concentration

1 mg/ml

Formulation

Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.

Storage

-20°C for one year

Background

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding d

Uniprot accession

Molecular weight

N/A

Gene ID

Human: 2064

Synonyms

ERBB2; HER2; MLN19; NEU; NGL; Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD antigen CD340

Research area

Tags & cell markers; Signal transduction; Cancer

Target protein

ERBB2

Recommended dilution

Application Dilution
ELISA 1:10000
IHC 1:200 - 1:1000
WB 1:500 - 1:2000

Images

Western Blot analysis using Neu Monoclonal antibody against truncated Neu recombinant protein.
Immunohistochemistry analysis of paraffin-embedded human breast intraductal carcinama tissues (A) and breast infiltrating ductal carcinoma tissues (B) showing membrane localization with DAB staining using Neu Monoclonal antibody.

Protocols

References

Customer reviews and Q&As

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Product size

Price

  • 50ul

    $180.00

  • 100ul

    $300.00

Add to Cart

Lead time: Within one week

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