Tyrosine-protein kinase ZAP-70

BT-MCA1307

Mouse

IgG

50ul,100ul

Monoclonal

Purified recombinant fragment of human ZAP-70 expressed in E. Coli.

Affinity purification

1 mg/ml

Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.

-20°C for one year

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.

Human: P43403; Mouse: P43404;

N/A

Human: 7535

ZAP70; SRK; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-chain associated protein; Syk-related tyrosine kinase

Others

ZAP70