NFKB

BT-AP00435

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized phosho peptide around human NF-κB p105 (Ser933)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines| oxidant-free radicals| ultraviolet irradiation| and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isof

Human: P19838; Mouse: P25799; Rat: Q63369;

Human: 4790; Mouse: 18033

NFKB; Nuclear factor NF-kappa-B p105 subunit; DNA-binding factor KBF1; EBP-1Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; Nuclear factor NF-kappa-B p50 subunit

Cell biology; Immunology; Signal transduction; Epigenetics and nuclear signaling; Cancer

NFKB1