APP

BT-AP00505

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized phosho peptide around human APP (Thr668)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation| while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition| two of the peptides are antimicrobial peptides| having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Human: P05067; Mouse: P12023; Rat: P08592;

Human: 351; Mouse: 11820; Rat: 54226

APP ;Thr668 ; Amyloid beta A4 protein; ABPP; APPI; APP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; CVAP; PreA4; Protease nexin-II; PN-II; N-APP; Soluble APP-alpha; S-APP-alpha; Soluble APP-beta; S-APP-beta; C99; Beta-amyloid protein 42; Beta-APP42; Beta-amyloid protein 40; Beta-APP40; C83; P3;42; P3;40; C80; Gamma-secretase C-terminal fragment 59; Amyloid intracellular domain 59; AICD-59; AID;59; Gamma-CTF;59; Gamma-secretase C-terminal fragment 57; Amyloid intracellular domain 57; AICD-57; AID;57; Gamma-CTF;57; Gamma-secretase C-terminal fragment 50; Amyloid intracellular domain 50; AICD-50; AID;50; Gamma-CTF;50; C31;

Neuroscience; Signal transduction

APP