Atm

BT-AP06213

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized peptide derived from human Atm (Acetyl Lys316)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus| it functions as a regulator of a wide variety of downstream proteins| including tumor suppressor proteins p53 and BRCA1| checkpoint kinase CHK2| checkpoint proteins RAD17 and RAD9| and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia| an autosomal recessive disorder.

Human: Q13315; Mouse: Q62388;

336160

Human: 472; Mouse: 11920

Atm ;Acetyl Lys316; Serine-protein kinase ATM; EC 2.7.11.1; Ataxia telangiectasia mutated; A-T mutated

Epigenetics and nuclear signaling; Cancer

ATM