Bim

BT-AP00801

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized phosho peptide around human Bim (Ser77)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.

Human: O43521; Mouse: O54918; Rat: O88498;

Human: 10018; Mouse: 12125; Rat: 64547

Bim (Ser77) ; Bcl-2-like protein 11; Bcl2-L-11; Bcl2-interacting mediator of cell death

Cell biology; Cancer; Metabolism; Signal transduction; Immunology; Neuroscience

BCL2L11