CARD11

BT-AP01038

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized phosho peptide around human CARD11 (Ser652)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family| a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family| which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10| a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells| this protein activated NF-kappaB and induced the phosphorylation of BCL10.

Human: Q9BXL7; Mouse: Q8CIS0;

Human: 84433; Mouse: 108723

CARD11 ;Ser652; Caspase recruitment domain-containing protein 11; CARD-containing MAGUK protein 1; Carma 1

Cancer; Cell biology; Epigenetics and nuclear signaling; Immunology; Signal transduction

CARD11