Caspase 4

BT-AP06907

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized peptide derived from human Caspase 4 (p10| Cleaved-Ala290)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

Catalytic activity:Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-.|Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1.|PTM:The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8.|Belongs to the peptidase C14A family.|Contains 1 CARD domain.|subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers| each one formed by a small and a large subunit.|tissue specificity:Widely expressed| with highest levels in spleen and lung. Moderate expression in heart and liver| low expression in skeletal muscle| kidney and testis. Not found in the brain.|

Human: P49662; Mouse: P70343;

41470

Human: 837; Mouse: 12363

Caspase 4 ;p10; Cleaved-Ala290; Caspase-4; CASP-4; EC 3.4.22.57; ICE;rel-II; Protease ICH-2; Protease TX; Caspase-4 subunit 1; Caspase-4 subunit 2;

Cancer; Cell biology; Metabolism

CASP4