Full product name
NAD-dependent protein deacetylase sirtuin-1
Code
BT-AP07980
Host
Rabbit
Isotype
IgG
Size
100ul,50ul,20ul
Clonality
Polyclonal
Immunogen
Synthesized phospho-peptide around the phosphorylation site of human SIRT1 (phospho Ser47)
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage
-20°C for 1 year
Background
This gene encodes a member of the sirtuin family of proteins| homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however| yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
Uniprot accession
Molecular weight
81681
Gene ID
Human: 23411; Mouse: 93759
Synonyms
NAD-dependent protein deacetylase sirtuin-1; SIRT1; SIR2L1; NAD-dependent protein deacetylase sirtuin-1; hSIRT1; Regulatory protein SIR2 homolog 1; SIR2-like protein 1; hSIR2
Research area
Cell biology; Epigenetics and nuclear signaling; Metabolism; Microbiology; Tags & cell markers
Target protein
SIRT1
