T-cell acute lymphocytic leukemia protein 1 homolog

BT-AP01689

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthesized acetyl-peptide derived from human TAL1/2 around the acetylation site of K221.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

alternative products:The splicing pattern is cell-lineage dependent|disease:A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.|The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.|Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.|PTM:Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia.|PTM:Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122| ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells| since it could not be observed in large vessel endothelial cells.|Contains 1 basic helix-loop-helix (bHLH) domain.|subunit:Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3| LDB1| TAL1 and TCF3.|tissue specificity:Leukemic stem cell.|

Human: P17542; Mouse: P22091;

Human: 6886; Mouse: 21349

T-cell acute lymphocytic leukemia protein 1 homolog/T-cell acute lymphocytic leukemia protein 2; TAL1; BHLHA17; SCL; TCL5; T-cell acute lymphocytic leukemia protein 1; TAL-1; Class A basic helix-loop-helix protein 17; bHLHa17; Stem cell protein; T-cell leukemia/lymphoma protein 5; TAL2; BHLHA19; T-cell acute lymphocytic leukemia protein 2; TAL-2; Class A basic helix-loop-helix protein 19; bHLHa19

Epigenetics and nuclear signaling; Developmental biology; Stem cells; Cancer; Cell biology

TAL1