TBC1 domain family member 4

BT-AP08119

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

The antiserum was produced against synthesized peptide derived from human AS160 around the phosphorylation site of Thr642. AA range:611-660

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein| and contains two phopshotyrosine-binding domains (PTB1 and PTB2)| a calmodulin-binding domain (CBD)| a Rab-GTPase domain| and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4)| important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane| suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin| this protein is phosphorylated| dissociates from GLUT4 vesicles| resulting in increased GLUT4 at the cell surface| and enhanced glucose transport. Ph

Human: O60343; Mouse: Q8BYJ6;

146563

Human: 9882; Mouse: 210789

TBC1 domain family member 4; TBC1D4; AS160; KIAA0603; TBC1 domain family member 4; Akt substrate of 160 kDa; AS160

Signal transduction

TBC1D4