DHE3

BT-AP02245

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthesized peptide derived from human DHE3

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

This gene encodes glutamate dehydrogenase| which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10| 18 and X.

Human: P00367; Mouse: P26443; Rat: P10860;

61380

Human: 2746; Mouse: 14661; Rat: 24399

DHE3

Cell biology; Metabolism; Signal transduction

GLUD1