FA11

BT-AP09941

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized peptide derived from human FA11 (light chain| Cleaved-Ile388)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen| which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI| an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains| resulting in activated factor XIa| a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome| a blood coagulation abnormality.

Human: P03951; Mouse: Q91Y47;

68750

Human: 2160; Mouse: 109821

FA11 ;light chain; Cleaved-Ile388; Coagulation factor XI; FXI; EC 3.4.21.27; Plasma thromboplastin antecedent; PTA; Coagulation factor XIa heavy chain; Coagulation factor XIa light chain;

Cardiovascular

F11