FACR1

BT-AP02620

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthesized peptide derived from human FACR1

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols| a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction| and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein| and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome| while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability| early-onset epilepsy| microcephaly| congenital cataracts| growth retardation| and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13.

Human: Q8WVX9; Mouse: Q922J9; Rat: Q66H50;

56650

Human: 84188; Mouse: 67420; Rat: 293173

FACR1

Metabolism

FAR1