GSTM5

BT-AP10307

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized peptide derived from human GSTM5

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present| eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha| kappa| mu| omega| pi| sigma| theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds| including carcinogens| therapeutic drugs| environmental toxins and products of oxidative stress| by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains| as well as in tissue expression patterns| to accommodate an increasing number of foreign compounds.

Human: P46439; Mouse: P48774; Rat: Q9Z1B2;

23980

Human: 2949; Mouse: 14866; Rat: 100912430

GSTM5

Metabolism; Signal transduction

GSTM5