Insulin Receptor beta

BT-AP03116

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized phosho peptide around human Insulin Receptor β (Tyr1345)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway| which regulates glucose uptake and release| as well as the synthesis and storage of carbohydrates| lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome| Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.

Human: P06213; Mouse: P15208; Rat: P15127;

Human: 3643; Mouse: 16337

Insulin Receptor β ;Tyr1345 ; Insulin receptor; IR; EC 2.7.10.1; CD antigen CD220; Insulin receptor subunit alpha; Insulin receptor subunit beta;

Cardiovascular; Metabolism; Neuroscience ; Signal transduction; Cancer

INSR