MCM2

BT-AP03565

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized phosho peptide around human MCM2 (Ser139)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4| 6| and 7| and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated| and thus regulated by| protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found| but the full-length nature of some variants has not been defined.

Human: P49736; Mouse: P97310;

Human: 4171; Mouse: 17216

MCM2 ;Ser139 ; DNA replication licensing factor MCM2; EC 3.6.4.12; Minichromosome maintenance protein 2 homolog; Nuclear protein BM28

Epigenetics and nuclear signaling

MCM2