MMP7

BT-AP03638

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized peptide derived from human MMP7 (Cleaved-Tyr95)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

Catalytic activity:Cleavage of 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in B chain of insulin. No action on collagen types I| II| IV| V. Cleaves gelatin chain alpha-2(I) > alpha-1(I).|cofactor:Binds 2 calcium ions per subunit.|cofactor:Binds 2 zinc ions per subunit.|The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion| thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.|Degrades casein| gelatins of types I| III| IV| and V| and fibronectin. Activates procollagenase.|Belongs to the peptidase M10A family.|

Human: P09237; Mouse: Q10738; Rat: P50280;

29370

Human: 4316; Mouse: 0; Rat: 25335

MMP7 ;Cleaved-Tyr95; Matrilysin; EC 3.4.24.23; Matrin; Matrix metalloproteinase-7; MMP-7; Pump-1 protease; Uterine metalloproteinase

Cancer; Cardiovascular; Cell biology; Signal transduction

MMP7