MMP8

BT-AP11342

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized peptide derived from human MMP8 (Cleaved-Leu101)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

Catalytic activity:Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7| this enzyme cleaves type III collagen more slowly than type I.|cofactor:Binds 2 zinc ions per subunit.|cofactor:Binds 3 calcium ions per subunit.|The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion| thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.|enzyme regulation:Cannot be activated without removal of the activation peptide.|Can degrade fibrillar type I| II| and III collagens.|Belongs to the peptidase M10A family.|Contains 4 hemopexin-like domains.|subcellular location:Stored in intracellular granules.|tissue specificity:Neutrophils.|

Human: P22894; Mouse: O70138; Rat: O88766;

51370

Human: 4317; Mouse: 17394; Rat: 63849

MMP8 ;Cleaved-Leu101; Neutrophil collagenase; EC 3.4.24.34; Matrix metalloproteinase-8; MMP-8; PMNL collagenase; PMNL-CL

Cancer; Cardiovascular; Cell biology; Signal transduction

MMP8