NEDD4L

BT-AP11514

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized peptide derived from human NEDD4L

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.08% sodium azide.

-20°C for 1 year

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates| thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel| ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Human: Q96PU5; Mouse: Q8CFI0;

Human: 23327; Mouse: 0

NEDD4L; E3 ubiquitin-protein ligase NEDD4-like; EC 6.3.2.-; NEDD4.2; Nedd4-2

Cell biology; Epigenetics and nuclear signaling

NEDD4L