p21

BT-AP03969

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized peptide derived from human p21 (Acetyl Lys154)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity| preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.|induction:By p53| mezerein (antileukemic compound) and interferon beta.|PTM:Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA.|Belongs to the CDI family.|tissue specificity:Expressed in all adult human tissues| with 5-fold lower levels observed in the brain.|

Human: P38936; Mouse: P39689;

18040

Human: 1026; Mouse: 12575

p21 ;Acetyl Lys154; Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; p21

Cancer; Cell biology; Epigenetics and nuclear signaling; Signal transduction

CDKN1A