PEN2

BT-AP11874

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized peptide derived from human PEN2

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

Presenilins| which are components of the gamma-secretase protein complex| are required for intramembranous processing of some type I transmembrane proteins| such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides| the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling| and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants.

Human: Q9NZ42; Mouse: Q9CQR7; Rat: Q6QI68;

11110

Human: 55851; Mouse: 66340; Rat: 292788

PEN2

Neuroscience

PSENEN