Rad50

BT-AP04379

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized phosho peptide around human Rad50 (Ser635)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50| a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein| cooperating with its partners| is important for DNA double-strand break repair| cell cycle checkpoint activation| telomere maintenance| and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.

Human: Q92878; Mouse: P70388; Rat: Q9JIL8;

Human: 10111; Rat: 64012

Rad50 ;Ser635; DNA repair protein RAD50; hRAD50; EC 3.6.-.-

Epigenetics and nuclear signaling

RAD50