RUBIC

BT-AP12356

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthesized peptide derived from human RUBIC

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.290% sodium azide.

-20°C for 1 year

The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains| an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling| and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Human: Q92622; Mouse: Q80U62;

Human: 9711; Mouse: 100502698

RUBIC; Run domain Beclin-1 interacting and cystein-rich containing protein; Rubicon; Beclin-1 associated RUN domain containing protein; Baron

Cancer; Cardiovascular; Cell biology; Metabolism

KIAA0226