S12A3

BT-AP12363

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthesized peptide derived from human S12A3

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome| a disease similar to Bartter's syndrome| that is characterized by hypokalemic alkalosis combined with hypomagnesemia| low urinary calcium| and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.

Human: P55017; Mouse: P59158; Rat: P55018;

112310

Human: 6559; Mouse: 20497; Rat: 54300

S12A3

Cardiovascular; Signal transduction; Metabolism

SLC12A3