Smad7

BT-AP12686

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized peptide derived from human Smad7 (Acetyl Lys70)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding| this complex translocates to the cytoplasm| where it interacts with TGF-beta receptor type-1 (TGFBR1)| leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.

Human: O15105; Mouse: O35253; Rat: O88406;

46860

Human: 4092; Mouse: 17131; Rat: 81516

Smad7 ;Acetyl Lys70; Mothers against decapentaplegic homolog 7; MAD homolog 7; Mothers against DPP homolog 7; Mothers against decapentaplegic homolog 8; MAD homolog 8; Mothers against DPP homolog 8; SMAD family member 7; SMAD 7; Smad7; hSMAD7

Epigenetics and nuclear signaling; Signal transduction

SMAD7