TAB2

BT-AP12946

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized phosho peptide around human TAB2 (Ser372)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

The protein encoded by this gene is an activator of MAP3K7/TAK1| which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6| MAP3K7 and TAB1| and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein| along with TAB1 and MAP3K7| also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK)| which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects| multiple types| 2 (CHTD2). Alternative splicing results in multiple transcript variants.

Human: Q9NYJ8; Mouse: Q99K90; Rat: Q5U303;

Human: 23118; Mouse: 68652; Rat: 308267

TAB2 ;Ser372 ; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; TAK1-binding protein 2; TAB-2; TGF-beta-activated kinase 1-binding protein 2

Signal transduction; Immunology

TAB2