TPOR

BT-AP13143

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized phosho peptide around human TPOR (Tyr626)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

In 1990 an oncogene| v-mpl| was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue| named| c-mpl| was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl| thrombopoietin| was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene| CD110| is a 635 amino acid transmembrane domain| with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic| emphasizing the important

Human: P40238; Mouse: Q08351;

Human: 4352; Mouse: 17480

TPOR ;Tyr626 ; Thrombopoietin receptor; TPO-R; Myeloproliferative leukemia protein; Proto-oncogene c-Mpl; CD antigen CD110

Immunology; Stem cells

MPL