WRN

BT-AP05511

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized peptide derived from human WRN

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism| including transcription| replication| recombination| and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity| and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing| this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome| an autosomal recessive disorder characterized by premature aging.

Human: Q14191; Mouse: O09053;

157520

Human: 7486; Mouse: 22427

WRN; Werner syndrome ATP-dependent helicase; EC 3.6.4.12; DNA helicase; RecQ-like type 3; RecQ3; Exonuclease WRN; EC 3.1.-.-; RecQ protein-like 2

Epigenetics and nuclear signaling

WRN