beta -Arrestin 1

BT-AP05811

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized phosho peptide around human β-Arrestin 1 (Ser412)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones| neurotransmitters| or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system| it is expressed at high levels in peripheral blood leukocytes| and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.

Human: P49407; Mouse: Q8BWG8; Rat: P29066;

Human: 408; Mouse: 109689; Rat: 25387

β-Arrestin 1 ;Ser412; Beta-arrestin-1; Arrestin beta-1

Signal transduction; Neuroscience

ARRB1