beta -Catenin

BT-AP13926

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized phosho peptide around human β-Catenin (Ser675)

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally| this protein binds to the product of the APC gene| which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC)| pilomatrixoma (PTR)| medulloblastoma (MDB)| and ovarian cancer. Alternative splicing results in multiple transcript variants.

Human: P35222; Mouse: Q02248; Rat: Q9WU82;

Human: 1499; Mouse: 12387; Rat: 84353

β-Catenin ;Ser675; Catenin beta-1; Beta-catenin

Cancer; Cardiovascular; Neuroscience; Signal transduction; Stem cells; Epigenetics and nuclear signaling

CTNNB1