Protein BEX3

BT-AP14453

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthesized peptide derived from human protein . at AA range: 1-80

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

-20°C for 1 year

The nuclear export signal is required for export from the nucleus and the interactions with itself and p75NTR/NGFR.,May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases.,miscellaneous:Binds transition metals.,PTM:Ubiquitinated. Degraded by the proteasome.,Belongs to the BEX family.,subcellular location:Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria.,subunit:Self-associates. Interacts with 14-3-3 epsilon (YWHAE). Interacts with DIABLO/SMAC (By similarity). Binds to the DEATH domain of p75NTR/NGFR.,tissue specificity:Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver.,

Human: Q00994; Mouse: Q9WTZ9; Rat: Q6PDU5;

Human: 27018

Protein BEX3 ;Brain-expressed X-linked protein 3;Nerve growth factor receptor-associated protein 1;Ovarian granulosa cell 13.0 kDa protein HGR74;p75NTR-associated cell death executor

Cancer; Cell biology

NGFRAP1