Bmi-1

BT-AP14458

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Recombinant Protein derived from human Bmi-1

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene.

Human: P35226;

Human: 100532731

Bmi-1; Polycomb complex protein BMI-1; Polycomb group RING finger protein 4; RING finger protein 51

Cancer; Cell biology; Epigenetics and nuclear signaling; Stem cells

BMI1